Coupling Genome Editing Tools with Delivery Systems

GenE-HumDi Workshop in Barcelona, 3-4 October 2024

UPDATE 10/09/2024:
NEW DEADLINE TO BOOK YOUR SEAT: SEPTEMBER 15th!
Registration for students, early career Scientist and Young Professionals is open. Secure your seat today: Showcase your research and network with field leaders: Poster a short-talk opportunities !

Genome editing tools and their delivery systems are advancing quickly, but they rely on each other to improve genome editing methods. This meeting will showcase the latest developments in both areas and foster connections and collaborations among scientists to boost the effectiveness of their research projects.

This is open event organized by Genome Editing for the treatment of Human Disease ( GeneHumdi| COST action 21113). A network committed to foster therapeutic genome editing therapeutic by nourishing collaborative networks and promoting early career scientist and industry engagement with the field. In this Workshop we will:

• 1. Identify and evaluate the existing endonuclease-independent platforms (EIP) and their potential uses in various applications.
• 2. Identify and evaluate the existing endonuclease-dependent platforms and their potential uses in various applications.
• 3. Create a comprehensive overview of the current delivery methods used for genome editing (GE) in various cell types for clinical applications.
• 4. Create a comprehensive overview of the current delivery methods used for in vivo genome editing (GE) in different animal models and clinical environments

This workshop is made possible thanks to a collaboration of GenE-Humdi and IDIBELL. We are thrilled to announce that several field leaders are now confirmed speakers:

• Dr. Marc Güell (Pompeu Fabra University, Spain)
• Dr. Vittoria. Raffa (Associate Professor in Molecular Biology, Ph.D. in Nanotechnology, M.Sc. in Chemical Engineering, Italy)
• Dr.  Giedrius Gasiunas (Caszyme, Lithuania)
• Dr. Peng Ling (Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, France)
• Dr. Julian Cerón Madrigal (Institut d’Investigació Biomèdica de Bellvitge, Spain)
• Dr. Karen O´Hanlon Cohrt (CRISPR Medicine News, Denmark)
• Dr. Alessia Cavazza (UCL, UK)
• Dr. Fco Javier Molina Estévez (GENyO, Spain)
• Dr. Laura Batlle Morera (CRG, Barcelona)
• Dr. Benabdellah Karim (GENyO, Spain)
• Dr. Gloria Gonzalez Aseguinolaza (DNA & RNA Medicine Division, Gene Therapy for Rare Diseases Department, Center for Applied Medical Research (CIMA), University of Navarra, IdisNA, Spain).
• Dr. Cecilia Jiménez-Mallebrera (Neuromuscular Unit. Institut de Recerca Sant Joan de Deu. Hospital Sant Joan de Déu Barcelona, Spain).
• Dr. Mariana Köber (Biomedical Research Network on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain)
• Dr. Carles J. Ciudad (Universitat de Barcelona, Spain)
• Dr. Jan Gorodkin (Department of Veterinary and Animal Sciences, Center for non-coding RNA in Technology and Health, University of Copenhagen, Denmark.).

PROVISIONAL PROGRAM

Thursday October 3^rd     14:00-20:00
14.00-14.30 Registration Workshop
14.30-14.45 Welcome form the GeneHumdi COST action (Karim Benabdel Lab, Francisco Martin)
14.45-15.00 Objectives of the workshop (Julian Cerón Madrigal)

Session 1: Mapping and Advancing Gene Editing Technologies
15.00-15.30 Talk 1 Marc Güell, title TBD
15.30-16.00 Talk 2 Giedrius Gausinas, Caszyme, title TBD
16.00-16.20 Talk 3 Julián Cerón, title TBD
16.20-16.40 Talk 4 Carles J. Ciudad, Ph. D. Endonuclease-independent platforms

16:40-18:00       Coffee break, poster session and Group Photo

Session 2: Exploring viruses for the CRISPR/Cas system delivery
18:00-18.30 Talk 5 VLP Alessia Cavazza
18:30-18:50 Talk 6 AAV Gloria Gonzalez Aseguinolaza
18:50-19.10 Talk 7 Samir Andaloussi, Extracellular Vesicles (to be confirmed)

19:10-20:00 Selected Short Talks
SHOWCASE YOUR RESEARCH HERE!!
APPLY TODAY

20:30 networking dinner
(The organization will propose a restaurant, but participation is voluntary and the expenses are not covered by the organization).

Friday October 4^rd           (9:30 to 14:30)

Session 3 Non-Viral Delivery Methods
9:30-10.00 Talk 9 Ling Peng, Synthetic Nanoparticles; Aix-Marseille Universite, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille.
10:00-10.30 Talk 8 Duško Lainšček ; LNPs

Session 4: Advances in Gene Editing:  Ex vivo aplication (HSCs, T cells and Ips)
10:30-10:50Talk 10 Karim Benabdellah Karim; Fulling cancer immunotherapy trough gene editing (T cells) .
10:50-11:10 Talk 11 Fco. Javier Molina Estevez; KI-Ep, a new genome editing platform for transcriptional control of gene expression through naturally occurring epigenetic modifications.
11:10-11:30 Talk 12 Laura Batlle Morera; iPS-Gene editing platform for disease modeling

11:30-12:00       Coffee break

12:00-12:30 Selected Short Talks
SHOWCASE YOUR RESEARCH HERE!!
APPLY TODAY

Session 6: Advances in Gene Editing: In Vivo Applications

12:30-12:50 Talk 13 Cecilia Jiménez-Mallebrera and Mariana Köber; Targeting muscle cells to treat Neuromuscular Disorders
12:50-13:10 Talk 14 Lourdes R Desviat, Centro de Biología Molecular Severo Ochoa UAM-CSIC; Targeting hepatocytes for the treatment of liver diseases
13:10-13:30  Talk 15 Lorea Blázquez, Department of Neurosciences, Biogipuzkoa Health Research Institute; Targeting the brain to tackle neurological disorders.

13:30-14:00 Talk 16 Karen O´Hanlon Cohrt (CRISPR Medicine News)
Crucial Role of Dissemination and Public Engagement in Gene Editing Projects

14:00-14:30        Julian Cerón, Closing remarks and workshop adjourn

Organizing committee and contacts:
Dr. Julian Cerón Madrigal
Dr. Francisco Martin Molina
Dr. Karim Benabdellah
Dr. Fco Javier Molina Estevez
GHM: Raquel Soriano e mail: raquel.soriano@juntadeandalucia.es